Vardenafil, known under the brand name Levitra is a prescription medication for male erectile dysfunction treatment. It belongs to a class of drugs called PDE5 inhibitors. Levitra increases blood flow to the penis, which helps gain and sustain an erection during sex. Levitra's active ingredient works on the chain of reactions within the penis during arousal, when the corpus cavernosa (two large chambers) in the male's penis fills with blood, resulting in an erection.
A penile erection happens when the penis fills with blood. This occurs when the blood vessels that supply the penis with blood expand (dilate), and the vessels that take blood away from the penis contract, resulting in an accumulation of blood in the penis.
Hypersensitivity to the active substance or to any of the excipients. The co-administration of vardenafil with nitrates or nitric oxide donors (such as amyl nitrite) in any form is contraindicated. Levitra is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischemic optic neuropathy (NAION), regardless of whether this episode was in connection or not with previous phosphodiesterase 5 (PDE5) inhibitor exposure.
Medicinal products for the treatment of erectile dysfunction should generally not be used in men for whom sexual activity is inadvisable (e.g. patients with severe cardiovascular disorders such as unstable angina or severe cardiac failure [New York Heart Association III or IV]). The safety of vardenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated until further information is available.