Clomid (clomiphene citrate or Serophene) is an oral medication that is commonly used for the treatment of infertility. It is often given to try to induce ovulation in women that do not develop and release an egg (ovulate) on their own. Women who do not ovulate (without drugs) are said to have a condition called anovulation. The most common cause of anovulation is polycystic ovarian syndrome, PCOS. This page is about Clomid treatment for women with polycystic ovarian syndrome, or with irregular menstrual cycles. Clomid for women with regular periods is discussed elsewhere
Clomid works best when the lowest dose that results in ovulation is used. If a woman ovulates on 50mg then increasing to 100mg is probably of no benefit - and may result in increased side effects. Many women will ovulate on 50 or 100mg, and some will require 150 mg in order to get an ovulatory response. Some pregnancies will occur on clomid doses above 100mg. However, increasing the Clomid dose to 200mg results in very few additional pregnancies.
Taking the drug. You take a clomid pill for five days at the start of your period. This helps your body produce more follicle-stimulating hormone (FSH), which makes the follicles grow. Follicles are the fluid-filled sacs where eggs mature.
Looking for the surge. After five days of taking clomid, your brain releases a "surge" of luteinizing hormone (LH), which signals the ovaries to release one or more mature eggs from the follicles when you ovulate. The LH surge happens five to 12 days after you take the last clomid pill.
Waiting for the release. The doctor monitors you closely to see whether your ovaries are ready to release an egg. A blood test or ultrasounds are done to monitor how the follicles are developing. You may also be asked to use an ovulation predictor kit or a basal body temperature chart to detect when you ovulate.
Timing the conception. Monitoring when eggs are released helps your doctor figure out the ideal time for you and your partner to have sex, or the best time to schedule a procedure such as IUI. And when an egg meets a healthy sperm in the fallopian tube, there's a chance you'll conceive.