Clomid is a so called fertility drug. This medication belongs to the class of medications known as ovulatory agents. It helps women to achieve pregnancy. It works inducing ovulation. The medicine stimulates production of follicle-stimulating hormone in the pituitary gland. It increases the amount of 3 hormones luteinizing hormone, follicle-stimulating hormone and gonadotropin-releasing hormone. As a result the body is tricked to believe that levels of estrogen are low and ovaries mature more follicles. Directions
The recommended dose is 50 mg per day before going to sleep. You should start to take Clomid from the 5th day of your menstrual cycle during 5 days. In case of no effect the dosage can be increased up to 150 mg. The maximum dose for this medication is 100 mg daily for 5 days. It is recommended not to use this medication for more than 6 cycles of treatment.
Clomid inhibits estrogen receptors in the hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic–pituitary–gonadal axis. Zuclomid, a more active isomer, stays bound for longer periods of time. Clomid is not a steroid drug.
In normal physiologic female hormonal cycling, at 7 days past ovulation, high levels of estrogen and progesterone produced from the corpus luteum inhibit GnRH, FSH and LH at the hypothalamus and anterior pituitary. If fertilization does not occur in the post-ovulation period the corpus luteum disintegrates due to a lack of beta-hCG. This would normally be produced by the embryo in the effort of maintaining progesterone and estrogen levels during pregnancy.
Therapeutically, Clomid is given early in the menstrual cycle. It is typically prescribed beginning on day 3 and continuing for 5 days. By that time, FSH level is rising steadily, causing development of a few follicles. Follicles in turn produce the estrogen, which circulates in serum. In the presence of Clomid, the body perceives a low level of estrogen, similar to day 22 in the previous cycle. Since estrogen can no longer effectively exert negative feedback on the hypothalamus, GnRH secretion becomes more rapidly pulsatile, which results in increased pituitary gonadotropin (FSH, LH) release. Increased FSH level causes growth of more ovarian follicles, and subsequently rupture of follicles resulting in ovulation. Ovulation occurs most often 6–7 days after a course of Clomid.