Thursday, 19 December 2013
According to a recent study, beta-amyloid plaques are not only a trait of Alzheimer disease, but they are also found in up to 30% of patients who die with acute traumatic brain injury, in which they occur largely in gray matter. Following traumatic brain injury, the beta-amyloid deposition seen in "normal" aging may be consequently sped up, but it has been difficult to measure amyloid binding in vivo.
The main objective of the study was to image a...
< .05 for both), but not in the thalamus or white matter. Autoradiography revealed [3H]PiB binding in neocortical gray matter, in regions corresponding to areas of amyloid deposition seen on immunocytochemistry. In the white matter, immunocytochemistry revealed beta-amyloid and beta-amyloid precursor protein, but no [3H]PiB binding.